Retromer logo
Exploded view of the retromer protein complex. The 3D structure is shown without the lipid membrane, to visualize how the proteins of the complex interact to create a “tunnel” with the outermost layer being the retromer trimer, the middle layer – generic tubulation proteins, and the innermost layer – the cargo receptor SORL1.Exploded view of the retromer protein complex. The 3D structure is shown without the lipid membrane, to visualize how the proteins of the complex interact to create a “tunnel” with the outermost layer being the retromer trimer, the middle layer – generic tubulation proteins, and the innermost layer – the cargo receptor SORL1.

Pioneering a new class of disease-modifying therapeutics to restore endolysosomal function in neurodegenerative disease

Impairment of the endolysosomal system has been shown to cause neurodegeneration. At Retromer Therapeutics, we are taking a translational approach, grounded in human genetics, to restore endolysosomal function and thereby, neuronal health.

3D artistic representation of three human neurons. The neuron bodies are slightly translucent, showing a hint of the organelles within. Two of the background neurons fade into the distance.3D artistic representation of three human neurons. The neuron bodies are slightly translucent, showing a hint of the organelles within. Two of the background neurons fade into the distance.
Our Science

An essential cellular system

The endolysosomal system processes proteins within the cell. Learn how this system works and how the retromer complex regulates it.

Learn Morearrow-icon
3D artistic representation of the human brain showing the side view of the cerebrum, cerebellum, and brainstem.3D artistic representation of the human brain showing the side view of the cerebrum, cerebellum, and brainstem.
Our Approach

A pathway with transformative therapeutic potential

Neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, and ALS affect millions of patients worldwide. Learn how we aim to restore endolysosomal function in neurodegenerative disease by addressing dysfunctional protein processing.

Learn Morearrow-icon
vector-line

A team of experts

We are the world’s leading experts in the role of the endolysosomal system in neurodegeneration. Learn more about our team and scientific advisors.